APIs and intermediates

We are able to provide the services of APIs and intermediates’ process development and scale up production. We have a demonstrated expertise in the design and preparation of multi-step APIs and intermediates which are used for drug candidate selections, vivo efficacy and toxicity studies, preclinical and pre-formulation studies. Our professional services ensure on-time delivery of cost-effective and high quality chemicals to meet the clients’ aggressive timelines.With the support of our cooperators, Dieckmann also has the capability of cGMP kilo lab and Pilot Plant manufactures which meet the western standards.

Manufacture
■ Novel compounds of discovery/medicinal chemistry programs
■ Scale up to support in vivo efficacy and toxicity studies
■ Manufacture of API and intermediates from gram to kilo scales
■ On-time delivery of low cost and high quality chemicals
■ CRO service

Process development
The process R&D team of Dieckmann consists of a number of chemical experts, who can ensure efficient and professional service of process development.
■ One separate kg level laboratories and one research Lab
■ One Manufacturing factory in Kunming.
■ Rapid process R&D
■ Process safety assessment
■ Process analysis development support
■ Integrated technical support and plant production
■ Commercial process development for advanced intermediates and APIs
■ On-time delivery of low cost and high quality chemicals
Our advantages

Experienced Special Process Skills in the Plant:
■ Ability to use pyrophoric chemicals
■ LAH, NaH, L-selectride, DIBAL-H, etc
■ Ability to use water or air sensitive chemicals
■ Grignard reagents, Borane reagents, lithium reagents

Special Process Reaction Types:
■ Chiral induction
■ Photolysis
■ Ozonelysis
■ Chiral resolution by salt formation
■ Chiral resolution by enzyme
■ Metal catalyzed coupling reactions
Some of Classic and superior products show below:
866594-60-7 Lacton
莱克酮
地瑞拉韦中间体

MF: C7H10O4
MW: 158.15
Assay:99%
Appearance:off-white solid。
MP:117.0~122.0℃
Lacton is used as the intermediate of Darunavir, a new generation of antiviral drug.it is mainly used for AIDS treatment In recent years. The demand for Lacton is on increase each year with the popularity of Darunavir. However,there are great technical difficulty for the synthesis process of Lacton, too many side-products, uncontrolled operation, the low recovery rate and high cost and so on, even which have a huge market prospects.there are only a few enterprises with the capacity of production in enormous quantities.
α(20℃):﹢131.0~﹢134.0°(C=1,CHCl3)
water:≤0.2%
477-84-9 Damnacanthal
MW.282.34
M.F: C16H10O5
Damnacanthal is an anthraquinone which acts as a p56lck tyrosine kinase inhibitor. It can be extracted from Morinda citrifolia. have long been used in traditional medicine for the treatment of cancer .
2927-71-1 2,4-Dichloro-5-Fluoropyrimidin
氟胞嘧啶中间体

M.F:C4HCl2FN2
M.W: 166.97
mp:37-41 °C(lit.)
bp:80 °C / 16mmHg
Assay:99%
2,4-Dichloro-5-Fluoropyrimidin is Mainly used as intermediate for the synthesis of flucytosine, a kind of anti-fungi drugs.
Appearance:off-white solid
80382-23-6 Loxoprofen Sodium
洛索洛芬钠

M.F: C15H17NaO3 2H2O
M.W: 304.32
Assay:>99%
Appearance: white solid
Loxoprofen sodium is first developed by Japan Sankyo, and got the first in the sale of the non-steroidal anti-inflammatory drugs.
154825-96-4 Fexofenadine
非索非那定

MF:C33H39NO4
MW:513.29
Assay: >99%
It can be used for the Intermediate for Fexofenadine hydrochloride
179897-89-3 5-Bromo-2-fluorobenzonitrile
非布司他中间体

MF:C7H3BrFN
MW:200.01
Assay: >98%
Appearance:off-white color to white crystal or crystalline powder
5-Bromo-2-fluorobenzonitrile be used for the intermediate of Febuxostate, a kind of anti-gout drug.
7250-55-7 Dimethyl 3-hydroxypentanedioate
MF:C7H12O5
MW:176.01
Assay: >99%
It can be used for the pharmaceutical intermediate
62865-36-5 DICLOMEZINE
哒菌清

MF:C11H8Cl2N2O
MW:255.1
Assay:>97%
Appearance:White solid
Diclomezine is a kind of treatment and protective fungicide. By inhibiting membrane formation and mycelial growth. So as to achieve sterilization purposes.
Application:Suitable for crops and rice, peanuts, lawn, etc. it is safe Under the recommended dose. Rice sheath blight control object and all kinds of sclerotinia, peanut white mildew and sclerotinia, lawn sheath blight, etc. Use stem leaf spray, the dose of 360 ~ 480 g (A.I.)/hm2
   
MF:C17H13NO5
MW:303.3
This compound is the intermediate of ibrutinib.
Ibrutinib also known as PCI-32765 and marketed under the name Imbruvica is an anticancer drug targeting B-cell malignancies. It is an orally-administered, selective and covalent inhibitor of the enzyme Bruton's tyrosine kinase (BTK).
1438383-89-1  
MF:C19H14Br2O3
MW:450.12
Assay:>99%
Appearance: yellow powder solid
The intermediate for Velpatasvir developed by Gilead Sciences.
Velpatasvi is an investigational pan-genotypic NS5A inhibitor, for the treatment of chronic hepatitis C virus (HCV) infection.
The.Sofosbuvir/Velpatasvir can be used for the Treatment of All Genotypes of Chronic Hepatitis C
73166-28-6 Effusol
灯心草菲酚

C17H16O2
White Powder
It is extract from plant rushes ,Anti-cancer active ingredient
  Dehydroeffusol
去氢厄弗酚

C17H14O2
White powder
It is extract from plant rushes ,Anti-cancer active ingredient